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Image Search Results
Journal:
Article Title: Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide
doi: 10.1073/pnas.2433468100
Figure Lengend Snippet: Isometric twitch tension evoked by maximal or approximately half-maximal single-twitch stimulation of EDL from WT (A)or nNOS-/- (B) mice, at 1% or 20% O2, and in the presence or absence of the NOS inhibitor, l-NAME. Histograms illustrate force production normalized for EDL cross-sectional area (M/cm2). Each bar represents measurements obtained from 8–10 individual EDL muscles. (A) For submaximal stimulation, significance was attained (P < 0.05) by the increase in twitch force at 1% vs. 20% O2 in the absence of l-NAME (*), by the decrease in twitch force at 1% O2 in the presence vs. absence of l-NAME (**) and by the increase in twitch force at 20% O2 in the presence vs. absence of l-NAME (***). At maximal twitch tension, the l-NAME-induced decrease in twitch force at 1% O2 was significant. (B) Twitch force was independent of pO2 in EDL from nNOS-/- mice. Note that maximal twitch force was significantly greater in nNOS-/- EDL (B) vs. WT EDL (A) at both 1% and 20% O2 and that this increase was also significant for submaximal twitch force at 20% O2 (P < 0.05).
Article Snippet:
Techniques: Muscles